Programmable Nucleases

Site-specific gene modification and highly specific in vitro cutting is enabled by nucleases that can be easily programmed with nucleic acids. NEB’s portfolio of Cas enzymes support RNA-guided programmable cutting, binding, and nicking of DNA. In addition to RNA-guided Cas enzymes, Tth Argonaute (TtAgo) (NEB #M0665) can be programmed with DNA, further expanding the range of available tools.

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Programmable Nucleases

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Programmable Nucleases

    Publications related to

    Programmable Nucleases

    • Morgan, R.D., Luyten, Y.A., Johnson, S.A., Clough, E.M., Clark, T.A. and Roberts, R.J. (2016) Novel m4C modification in type I restriction-modification systems. Nucleic Acids Res; Nov, 2;44(19):9413-9425. PubMedID: 27580720
    • Roberts, R.J., Vincze, T., Posfai, J., Macelis, D. (2014) REBASE - A database for DNA restriction and modification: enzymes, genes and genomes Nucleic Acids Res;
    • Roberts, R.J., Vincze, T., Posfai, J., Macelis, D. (2015) REBASE - A database for DNA restriction and modification: enzymes, genes and genomes Nucleic Acids Res; 43, D298-D299. PubMedID: 25378308
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